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The purpose of this review is to chart the course of inflammation as it unfolds in FD

29 Given the major role of hepatic lipid balance in the pathogenesis of NASH, treatment strategies can be considered in terms of reducing fat inflow into the liver or enhancing fat metabolism in the liver

Repurposing of long-acting incretin-based therapies, including the GLP-1 receptor agonist semaglutide, the dual GLP-1/gastric inhibitory polypeptide (GIP) receptor agonist tirzepatide, and the triple GLP-1/GIP/glucagon agonist retatrutide, may offer a promising strategy treating AUD

doi:10.1056/NEJMoa2208601 19

Improved Health The medication-first approach has the potential to positively impact other health conditions, offering a holistic improvement in well-being